priors.science/reviews/treatment-resistant-depression

Treatment Resistant Depression

The current evidence on 6 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

6claims tracked
60primary papers reviewed
4 Jun 2026latest evidence review
Weeklyre-scored against new papers
0 Established · 5 Likely · 1 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableElectroconvulsive therapy remission in treatment-resistant depressionNeurostimulationLikely84%10
StableIntravenous ketamine rapid responseRapid Acting GlutamatergicLikely75%10
StableAntipsychotic augmentationPharmacological AugmentationLikely74%10
StableEsketamine adjunct in treatment-resistant depressionRapid Acting GlutamatergicLikely74%10
StableRepetitive transcranial magnetic stimulation reduces treatment-resistant depression symptomsNeurostimulationLikely73%10
StablePsilocybin in treatment-resistant depressionNovel EmergingUncertain58%10
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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