priors.science/reviews/tnf-alpha-inhibitors

TNF Alpha Inhibitors

The current evidence on 14 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

14claims tracked
90primary papers reviewed
10 Aug 2026latest evidence review
Weeklyre-scored against new papers
9 Established · 5 Likely · 0 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
TNF-alpha inhibitors reduce signs and symptoms of rheumatoid arthritis versus placeboRAEstablished96%2
TNF-alpha inhibitors combined with methotrexate are superior to methotrexate monotherapy in RARAEstablished95%6
TNF-alpha inhibitors increase the risk of serious infections including tuberculosis reactivationSafEstablished95%6
Infliximab and adalimumab induce remission in moderate-to-severe Crohn's diseaseIBDEstablished94%6
TNF-alpha inhibitors are effective in ankylosing spondylitis and axial spondyloarthritisSpaEstablished92%5
TNF-alpha inhibitor biosimilars are equivalent in efficacy and safety to reference biologicsBioEstablished91%6
TNF-alpha inhibitors inhibit radiographic joint damage progression in RARAEstablished91%6
TNF-alpha inhibitors achieve PASI 75 response in moderate-to-severe plaque psoriasisPsoEstablished90%2
TNF-alpha inhibitors are effective in psoriatic arthritisSpaEstablished88%2
TNF-alpha inhibitors are contraindicated in moderate-to-severe heart failureSafLikely84%6
TNF-alpha inhibitors can trigger demyelinating disease and are contraindicated in multiple sclerosisSafLikely82%6
TNF-alpha inhibitors maintain steroid-free remission in ulcerative colitisIBDLikely80%1
Serum drug level monitoring improves TNF-alpha inhibitor outcomes in inflammatory bowel diseaseBioLikely72%1
TNF-alpha inhibitors are associated with increased lymphoma riskSafLikely72%6
Track TNF Alpha Inhibitors.
These claims are re-scored against new papers every week. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it — confidently false as stated.