priors.science/reviews/thrombopoietin-receptor-agonists

Thrombopoietin Receptor Agonists

The current evidence on 12 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

12claims tracked
50primary papers reviewed
6 Jul 2026latest evidence review
Weeklyre-scored against new papers
6 Established · 6 Likely · 0 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableRomiplostim increases platelet counts and reduces bleeding in chronic immune thrombocytopeniaItpEstablished96%4
StableEltrombopag increases platelet counts and reduces bleeding in chronic immune thrombocytopeniaItpEstablished94%4
StableTPO receptor agonists reduce clinically significant bleeding events in ITPItpEstablished91%4
StableTPO receptor agonists are associated with an increased risk of thromboembolic eventsSafEstablished90%4
StableEltrombopag produces haematologic responses in refractory severe aplastic anemiaAaEstablished88%4
StableEltrombopag added to immunosuppressive therapy improves response rates in severe aplastic anemiaAaEstablished86%4
StableAvatrombopag increases platelets in chronic liver disease thrombocytopenia before proceduresLDLikely82%4
StableTPO receptor agonists allow splenectomy avoidance in steroid-refractory ITPItpLikely80%4
StableEltrombopag increases platelets in hepatitis C thrombocytopenia to enable antiviral treatmentLDLikely76%4
StableLong-term TPO receptor agonist use is associated with bone marrow reticulin fibrosisSafLikely74%4
StableTPO receptor agonists do not improve outcomes in myelodysplastic syndrome and may increase blast progression riskMDSLikely72%4
StableA minority of ITP patients achieve sustained platelet responses off TPO receptor agonistsItpLikely68%4
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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