priors.science/reviews/ssris-and-snris

Ssris and Snris

The current evidence on 15 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

15claims tracked
91primary papers reviewed
10 Aug 2026latest evidence review
Weeklyre-scored against new papers
8 Established · 7 Likely · 0 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
SSRIs and SNRIs reduce depressive symptoms versus placebo in MDDMDDEstablished97%1
SSRIs and SNRIs cause sexual dysfunction in 30-40% of treated patientsSafEstablished94%6
SSRIs and SNRIs are effective first-line treatments in generalised anxiety disorderAnxEstablished93%6
Escitalopram and sertraline have the best efficacy and acceptability profile among antidepressantsCMPEstablished88%6
Paroxetine and venlafaxine cause more severe discontinuation syndrome than other agentsSafEstablished88%6
Duloxetine reduces pain in fibromyalgia and diabetic peripheral neuropathyCMPEstablished87%6
SSRIs reduce symptoms in obsessive-compulsive disorderAnxEstablished86%1
SSRIs increase suicidal ideation in children and adolescentsSafEstablished85%1
Antidepressant effect size is small versus placebo in mild-to-moderate depressionMDDLikely84%6
Antidepressant effect size increases with baseline depression severityMDDLikely82%6
Sertraline and paroxetine reduce PTSD symptom severity versus placeboAnxLikely80%6
SSRIs are safe and reduce depression in patients after myocardial infarctionSPCLikely80%6
Venlafaxine causes dose-dependent blood pressure elevationSafLikely76%6
SSRI use in late pregnancy is associated with neonatal adaptation syndromeSPCLikely75%6
SNRIs are more effective than SSRIs for pain symptoms comorbid with depressionCMPLikely72%6
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These claims are re-scored against new papers every week. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it — confidently false as stated.