priors.science/reviews/ssris-and-snris

Ssris and Snris

The current evidence on 15 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

15claims tracked
91primary papers reviewed
6 Jul 2026latest evidence review
Weeklyre-scored against new papers
7 Established · 8 Likely · 0 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableSSRIs and SNRIs reduce depressive symptoms versus placebo in MDDMDDEstablished97%6
StableSSRIs and SNRIs cause sexual dysfunction in 30-40% of treated patientsSafEstablished94%6
StableSSRIs and SNRIs are effective first-line treatments in generalised anxiety disorderAnxEstablished93%6
StableEscitalopram and sertraline have the best efficacy and acceptability profile among antidepressantsCMPEstablished88%6
StableParoxetine and venlafaxine cause more severe discontinuation syndrome than other agentsSafEstablished88%6
StableDuloxetine reduces pain in fibromyalgia and diabetic peripheral neuropathyCMPEstablished87%6
StableSSRIs reduce symptoms in obsessive-compulsive disorderAnxEstablished86%6
StableAntidepressant effect size is small versus placebo in mild-to-moderate depressionMDDLikely84%6
StableSSRIs increase suicidal ideation in children and adolescentsSafLikely84%6
StableAntidepressant effect size increases with baseline depression severityMDDLikely82%6
StableSertraline and paroxetine reduce PTSD symptom severity versus placeboAnxLikely80%6
StableSSRIs are safe and reduce depression in patients after myocardial infarctionSPCLikely80%6
StableVenlafaxine causes dose-dependent blood pressure elevationSafLikely76%6
StableSSRI use in late pregnancy is associated with neonatal adaptation syndromeSPCLikely75%6
StableSNRIs are more effective than SSRIs for pain symptoms comorbid with depressionCMPLikely72%6
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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