priors.science/reviews/migraine

Migraine

The current evidence on 22 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

22claims tracked
311primary papers reviewed
9 Aug 2026latest evidence review
Weeklyre-scored against new papers
5 Established · 10 Likely · 6 Uncertain · 1 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Anti-CGRP monoclonal antibodies reduce migraine daysCgrpEstablished88%3
Intravenous CGRP infusion triggers migraine attacks in migraineurs.MechanismEstablished88%20
Triptans relieve acute migraineAcuteEstablished87%20
OnabotulinumtoxinA reduces chronic migraine daysEstablishedEstablished86%4
Atogepant reduces episodic migraine daysCgrpEstablished85%7
Gepants relieve acute migraineAcuteLong-standingLikely84%20
Lasmiditan relieves acute migraineAcuteLong-standingLikely84%20
CGRP is elevated during spontaneous migraine attacks.MechanismLikely83%20
Topiramate reduces migraine frequencyEstablishedLikely82%10
PACAP infusion triggers migraine attacks in migraineurs.MechanismLikely82%14
Remote electrical neuromodulation aborts acute migraine.NeuromodLong-standingLikely81%20
Aerobic exercise reduces migraineBehaviouralLikely79%22
Cognitive behavioural therapy reduces migraine burden.BehaviouralLikely76%19
Cortical spreading depression underlies the migraine aura.MechanismLikely73%20
Migraine linked to depressionComorbidLikely72%22
Sumatriptan-naproxen beats monotherapyAcuteLong-standingUncertain69%20
Hormones trigger menstrual migraineTriggersUncertain66%18
Non-invasive vagus nerve stimulation reduces migraine.NeuromodLong-standingUncertain63%17
Stress triggers migraine attacksTriggersUncertain56%20
Diet triggers migraine attacksTriggersUncertain56%19
Magnesium reduces migraine frequencyEstablishedUncertain52%10
Patent foramen ovale closure reduces migraine.ComorbidDoubtful34%20
Track Migraine.
These claims are re-scored against new papers every week. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it — confidently false as stated.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.