priors.science/reviews/migraine

Migraine

The current evidence on 22 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

22claims tracked
311primary papers reviewed
17 Jul 2026latest evidence review
Weeklyre-scored against new papers
4 Established · 13 Likely · 5 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableIntravenous CGRP infusion triggers migraine attacks in migraineurs.MechanismEstablished88%20
StableTriptans relieve acute migraineAcuteEstablished87%20
StableAnti-CGRP monoclonal antibodies reduce migraine daysCgrpEstablished86%10
StableOnabotulinumtoxinA reduces chronic migraine daysEstablishedEstablished86%10
StableGepants relieve acute migraineAcuteLikely84%20
StableLasmiditan relieves acute migraineAcuteLikely84%20
StableAtogepant reduces episodic migraine daysCgrpLikely83%10
StableCGRP is elevated during spontaneous migraine attacks.MechanismLikely83%20
StableTopiramate reduces migraine frequencyEstablishedLikely82%10
StablePACAP infusion triggers migraine attacks in migraineurs.MechanismLikely82%14
StableRemote electrical neuromodulation aborts acute migraine.NeuromodLikely81%20
StableAerobic exercise reduces migraineBehaviouralLikely76%18
StableCognitive behavioural therapy reduces migraine burden.BehaviouralLikely75%18
StableCortical spreading depression underlies the migraine aura.MechanismLikely73%20
StableMigraine linked to depressionComorbidLikely71%19
StableSumatriptan-naproxen beats monotherapyAcuteLikely69%20
StableHormones trigger menstrual migraineTriggersLikely66%18
StableNon-invasive vagus nerve stimulation reduces migraine.NeuromodUncertain63%17
StableStress triggers migraine attacksTriggersUncertain56%20
StableDiet triggers migraine attacksTriggersUncertain56%19
StableMagnesium reduces migraine frequencyEstablishedUncertain52%10
StablePatent foramen ovale closure reduces migraine.ComorbidUncertain47%14
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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