priors.science/reviews/epilepsy-management

Epilepsy Management

The current evidence on 6 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

6claims tracked

133primary papers reviewed

9 Aug 2026latest evidence review

Weeklyre-scored against new papers

4 Established · 1 Likely · 0 Uncertain · 0 Doubtful · 1 Refuted | four-reviewer panel · PICO Framework

ClaimStandingEvidence certaintyCorpus

Fenfluramine in Dravet syndromeNovel MechanismsEstablished93%23

Resective surgery for drug-resistant temporal lobe epilepsySurgical DreEstablished92%24

Cannabidiol in Lennox-Gastaut syndromeNovel MechanismsEstablished88%21

Valproate superior in generalised epilepsyAsm EfficacyEstablished86%20

Vagus nerve stimulation reduces seizure frequencySurgical DreLikely82%29

Levetiracetam non-inferior to lamotrigineAsm EfficacyRefuted29%19

Track Epilepsy Management.

These claims are re-scored against new papers every week. Track this topic for the full review, including each claim’s challenge and the papers behind it.

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Standing — what the evidence certainty means

Established≥ 85%Strong, consistent evidence. Unlikely to change.

Likely70–84%Well supported, with some gaps or indirect evidence.

Uncertain50–69%Mixed or limited evidence. Genuinely open.

Doubtful30–49%Little support; the weight of evidence leans against it.

Refuted< 30%The evidence contradicts it — confidently false as stated.