priors.science/reviews/dry-eye-disease-treatment

Dry Eye Disease Treatment

The current evidence on 18 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

18claims tracked
211primary papers reviewed
9 Aug 2026latest evidence review
Weeklyre-scored against new papers
5 Established · 12 Likely · 1 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Cyclosporine reduces corneal stainingCyclosporineEstablished89%16
Perfluorohexyloctane superior to saline in meibomian gland dysfunctionPerfluorohexyloctaneEstablished89%7
Perfluorohexyloctane improves evaporative dry eye signsPerfluorohexyloctaneEstablished87%15
Diquafosol improves tear film break-up time in dry eyeSecretagoguesEstablished86%20
Lifitegrast improves symptom scoresLifitegrastEstablished85%10
Intense pulsed light improves meibomian gland functionIntense Pulsed LightLikely84%19
Punctal plugs increase Schirmer test scoresPunctal OcclusionLikely83%16
Punctal occlusion improves aqueous-deficient dry eye diseasePunctal OcclusionLikely82%15
Autologous serum improves severe refractory dry eyeAutologous SerumLikely80%16
Cyclosporine increases Schirmer test scoresCyclosporineLikely80%23
Omega-3 does not improve dry eye disease symptomsOmega 3 SupplementationLong-standingLikely78%14
Thermal pulsation improves meibomian gland dysfunction symptomsMGD Thermal TreatmentLikely78%15
Autologous serum in Sjogren syndrome dry eyeAutologous SerumLikely76%11
Omega-3 does not improve dry eye disease signsOmega 3 SupplementationLong-standingLikely76%14
Rebamipide improves goblet cell densitySecretagoguesLong-standingLikely76%13
Intense pulsed light reduces dry eye symptoms in meibomian gland dysfunctionIntense Pulsed LightLikely74%15
Lifitegrast reduces inferior corneal stainingLifitegrastLong-standingLikely71%12
LipiFlow benefit persists at 12 monthsMGD Thermal TreatmentUncertain65%13
Track Dry Eye Disease Treatment.
These claims are re-scored against new papers every week. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it — confidently false as stated.
Where the evidence sits in time
Long-standingMost of this evidence is older than the rest of this field.