priors.science/reviews/dry-eye-disease-treatment

Dry Eye Disease Treatment

The current evidence on 18 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

18claims tracked
209primary papers reviewed
29 May 2026latest evidence review
Weeklyre-scored against new papers
4 Established · 14 Likely · 0 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StablePerfluorohexyloctane superior to saline in meibomian gland dysfunctionPerfluorohexyloctaneEstablished89%10
StableCyclosporine reduces corneal stainingCyclosporineEstablished88%17
StablePerfluorohexyloctane improves evaporative dry eye signsPerfluorohexyloctaneEstablished87%13
StableCyclosporine increases Schirmer test scoresCyclosporineEstablished86%22
StableIntense pulsed light improves meibomian gland functionIntense Pulsed LightLikely83%13
StableLifitegrast improves symptom scoresLifitegrastLikely83%10
StablePunctal plugs increase Schirmer test scoresPunctal OcclusionLikely83%17
StableDiquafosol improves tear film break-up time in dry eyeSecretagoguesLikely83%18
StablePunctal occlusion improves aqueous-deficient dry eye diseasePunctal OcclusionLikely82%16
StableThermal pulsation improves meibomian gland dysfunction symptomsMGD Thermal TreatmentLikely80%15
StableAutologous serum improves severe refractory dry eyeAutologous SerumLikely78%15
StableOmega-3 does not improve dry eye disease symptomsOmega 3 SupplementationLikely78%16
StableAutologous serum in Sjogren syndrome dry eyeAutologous SerumLikely76%11
StableOmega-3 does not improve dry eye disease signsOmega 3 SupplementationLikely76%15
StableRebamipide improves goblet cell densitySecretagoguesLikely76%14
StableIntense pulsed light reduces dry eye symptoms in meibomian gland dysfunctionIntense Pulsed LightLikely74%14
StableLifitegrast reduces inferior corneal stainingLifitegrastLikely72%11
StableLipiFlow benefit persists at 12 monthsMGD Thermal TreatmentLikely65%14
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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