priors.science/reviews/cardiovascular-inflammation-secondary-prevention

Cardiovascular Inflammation Secondary Prevention

The current evidence on 8 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

8claims tracked
103primary papers reviewed
2 Jun 2026latest evidence review
Weeklyre-scored against new papers
5 Established · 2 Likely · 1 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableHigh-sensitivity C-reactive protein predicts major adverse cardiovascular events beyond low-density lipoprotein controlHsCRP Residual RiskEstablished89%13
StableMethotrexate null for cardiovascular preventionAnti Inflammatory AgentsEstablished87%12
StableIL-1 beta inhibition reduces major adverse cardiovascular eventsCytokine TargetingEstablished87%13
StableColchicine major adverse cardiovascular events in chronic coronary diseaseAnti Inflammatory AgentsEstablished86%15
StableIL-6 predicts major adverse cardiovascular events in coronary patientsCytokine TargetingEstablished86%14
StableResidual inflammatory risk post-myocardial infarctionHsCRP Residual RiskLikely83%12
StableColchicine major adverse cardiovascular events post-myocardial infarctionAnti Inflammatory AgentsLikely67%15
StableIL-6 inhibition reduces major adverse cardiovascular events in chronic kidney diseaseCytokine TargetingUncertain61%9
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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