priors.science/reviews/car-t-cell-therapy

CAR-T Cell Therapy

The current evidence on 11 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

11claims tracked
179primary papers reviewed
4 Jun 2026latest evidence review
Weeklyre-scored against new papers
5 Established · 5 Likely · 1 Uncertain · 0 Doubtful  |  four-reviewer panel · PICO Framework
SignalClaimStandingEvidence certaintyCorpus
StableCAR-T versus autologous stem cell transplant, second-line diffuse large B-cell lymphoma (ZUMA-7/TRANSFORM)Dlbcl CartEstablished89%20
StableCiltacabtagene progression-free survival in relapsed/refractory multiple myeloma (CARTITUDE-4)Myeloma CartEstablished89%20
StableAxicabtagene overall survival benefit in third-line-or-later diffuse large B-cell lymphoma (ZUMA-1)Dlbcl CartEstablished88%9
StableTisagenlecleucel complete remission in paediatric B-cell acute lymphoblastic leukaemia (ELIANA)All CartEstablished86%19
StableAxicabtagene complete response in third-line-or-later follicular lymphoma (ZUMA-5)Indolent CartEstablished86%15
StableIdecabtagene overall response rate in triple-class refractory multiple myeloma (KarMMa)Myeloma CartLikely84%18
StableBrexucabtagene minimal residual disease-negative mantle cell lymphoma (ZUMA-2)Indolent CartLikely81%16
StableCytokine release syndrome and neurotoxicity syndrome: predictors and management in CAR-TCart ToxicityLikely81%8
StableBrexucabtagene in adult relapsed/refractory B-cell acute lymphoblastic leukaemia (ZUMA-3)All CartLikely78%14
StableTisagenlecleucel overall survival in relapsed diffuse large B-cell lymphoma (JULIET)Dlbcl CartLikely77%20
StableCD19 antigen escape as CAR-T resistance mechanismCart ToxicityUncertain53%20
Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely65–84%Well supported, with some gaps or indirect evidence.
Uncertain40–64%Mixed or limited evidence. Genuinely open.
Doubtful15–39%Little support; the weight of evidence leans against it.
Refuted< 15%The evidence contradicts it — confidently false as stated.
Recent signal
strengthenedNew evidence raised the certainty since the last review.
weakenedNew evidence lowered the certainty since the last review.
newA claim added to the review recently.
StableNo recent change to the standing.
Standing, evidence certainty and corpus are always shown. The study behind each move, why it moved, and the sceptic’s challenge are delivered to subscribers.
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