priors.science/reviews/anti-cgrp-antibodies

Anti CGRP Antibodies

The current evidence on 17 claims, ordered from most established to most contested. Each score is the panel’s evidence certainty — how firmly the literature supports the claim as stated.

17claims tracked
167primary papers reviewed
9 Aug 2026latest evidence review
Weeklyre-scored against new papers
4 Established · 7 Likely · 5 Uncertain · 1 Doubtful  |  four-reviewer panel · PICO Framework
ClaimStandingEvidence certaintyCorpus
Monthly migraine days in episodic migraineEpisodic MigraineEstablished88%26
Erenumab tolerability versus topiramateComparative EfficacyEstablished86%19
Monthly headache days in chronic migraineChronic MigraineEstablished85%27
Low discontinuation with CGRP antibodiesSafetyEstablished85%19
Responder rates in episodic migraineEpisodic MigraineLikely80%24
Galcanezumab for episodic cluster headacheCluster HeadacheLikely75%20
Long-term CGRP antibody efficacyChronic MigraineLikely74%20
Erenumab and blood pressure increaseSafetyLikely74%21
Medication overuse headache treatment without detoxificationMedication OveruseLikely73%18
Real-world CGRP antibody effectivenessReal WorldLikely73%18
Anti-CGRP antibodies versus oral preventives in refractory migraineComparative EfficacyLikely72%18
Switching CGRP antibodies in non-respondersReal WorldUncertain68%20
Comparable CGRP antibody efficacyEpisodic MigraineUncertain64%20
Eptinezumab acute migraine pain freedomEpisodic MigraineUncertain60%16
Medication overuse headache remission with CGRP antibodiesMedication OveruseUncertain57%18
Cardiovascular safety of CGRP antibodiesSafetyUncertain55%17
Anti-CGRP antibodies for chronic cluster headacheCluster HeadacheDoubtful30%19
Track Anti CGRP Antibodies.
These claims are re-scored against new papers every week. Track this topic for the full review, including each claim’s challenge and the papers behind it.
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Standing — what the evidence certainty means
Established≥ 85%Strong, consistent evidence. Unlikely to change.
Likely70–84%Well supported, with some gaps or indirect evidence.
Uncertain50–69%Mixed or limited evidence. Genuinely open.
Doubtful30–49%Little support; the weight of evidence leans against it.
Refuted< 30%The evidence contradicts it — confidently false as stated.