Question · from the living review of Predictive Biomarkers Immunotherapy →

Is it true that early circulating tumour DNA clearance during immune checkpoint inhibitor therapy is associated with improved treatment response and survival outcomes?

Likely updated weekly · as of

Priors rates this Likely — 75 out of 100, updated weekly. Probably — but it is not fully settled. On the claim that early circulating tumour DNA clearance during immune checkpoint inhibitor therapy is associated with improved treatment response and survival outcomes, its four-agent AI review panel weighs 10 primary peer-reviewed studies.

RefutedDoubtfulUncertainLikelyEstablished
where this sits on Priors’ scale of how settled the evidence is

How we got this answer. Priors runs each claim through a panel of four AI agents, each acting as a specialist expert reviewer. They read the published, peer-reviewed studies behind the question, judge how strong, consistent and reliable the evidence is, and turn that judgment into a single rating from 0 to 100 — refreshed every week as new studies appear, so it reflects where the evidence stands today, not a one-off verdict.

The traceable studies behind this rating — and the panel’s single strongest counter-argument to it — are in Priors’ full Predictive Biomarkers Immunotherapy review.

Related Oncology — solid tumours questions

Is it true that MSI-H/dMMR status is the most validated pan-tumour predictive biomarker for immune checkpoint inhibitor response, with consistent high response rates across all tested solid tumour types? → Is it true that dMMR/MSI-H endometrial carcinoma shows robust immune checkpoint inhibitor response both in monotherapy and in combination with targeted agents? → Is it true that different PD-L1 assay clones and scoring methods are not interchangeable and produce clinically significant discordant results across cancer types? → Is it true that PD-L1 tumour proportion score (TPS) ≥50% is a validated predictive biomarker for pembrolizumab monotherapy benefit in previously untreated advanced NSCLC? →
Reflects the peer-reviewed evidence as of 17 July 2026 and updates as new studies land. AI can make mistakes. Not medical advice.