Question · from the living review of Targeted Therapy Prostate Cancer →

Is it true that 177Lu-PSMA-617 (lutetium vipivotide tetraxetan) significantly improves overall survival and radiographic progression-free survival in PSMA-positive mCRPC after prior AR inhibitor and docetaxel (VISION trial)?

Established updated weekly · as of

Priors rates this Established — 88 out of 100, updated weekly. Yes — this looks well established. On the claim that 177Lu-PSMA-617 (lutetium vipivotide tetraxetan) significantly improves overall survival and radiographic progression-free survival in PSMA-positive mCRPC after prior AR inhibitor and docetaxel (VISION trial), its four-agent AI review panel weighs 20 primary peer-reviewed studies.

RefutedDoubtfulUncertainLikelyEstablished
where this sits on Priors’ scale of how settled the evidence is

How we got this answer. Priors runs each claim through a panel of four AI agents, each acting as a specialist expert reviewer. They read the published, peer-reviewed studies behind the question, judge how strong, consistent and reliable the evidence is, and turn that judgment into a single rating from 0 to 100 — refreshed every week as new studies appear, so it reflects where the evidence stands today, not a one-off verdict.

The traceable studies behind this rating — and the panel’s single strongest counter-argument to it — are in Priors’ full Targeted Therapy Prostate Cancer review.

Related Oncology — solid tumours questions

Is it true that adding abiraterone acetate plus prednisone to androgen deprivation therapy significantly improves overall survival in metastatic hormone-sensitive prostate cancer (LATITUDE and STAMPEDE trials)? → Is it true that enzalutamide significantly improves overall survival compared to placebo in chemotherapy-naive metastatic castration-resistant prostate cancer (PREVAIL trial)? → Is it true that enzalutamide significantly improves metastasis-free survival in high-risk non-metastatic castration-resistant prostate cancer (PROSPER trial, HR 0.29 for MFS)? → Is it true that adding enzalutamide or darolutamide to androgen deprivation therapy plus docetaxel significantly improves overall survival in metastatic hormone-sensitive prostate cancer (ARCHES, ENZAMET, ARASENS trials)? →
Reflects the peer-reviewed evidence as of 17 July 2026 and updates as new studies land. AI can make mistakes. Not medical advice.